Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22737347 | 1.00 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4HRH4GPR119 | |
| SCHEMBL27363472 | 0.86 | GPR119 (0.55) | CHRNA7CHRNB2CHRNA4HRH4GPR119 | |
| SCHEMBL27363153 | 0.80 | ACACB (0.34) | GPR119KCNH2ACACBSLC6A9 | |
| SCHEMBL24197271 | 0.79 | BPTF (0.43) | CHRNA7CHRNB2CHRNA4GPR119CHRNB4 | |
| SCHEMBL17972943 | 0.78 | TSHR (0.39) | GPR119KCNH2ACACBSLC6A9 | |
| SCHEMBL16472351 | 0.78 | ACACB (0.39) | GPR119KCNH2ACACBSLC6A9HCRTR1 | |
| SCHEMBL81442 | 0.77 | ACACB (0.39) | HRH4GPR119KCNH2ACACB | |
| SCHEMBL27363632 | 0.77 | CHRNA7 (0.48) | CHRNA7CHRNB2CHRNA4HRH4GPR119 | |
| SCHEMBL17973025 | 0.76 | HRH3 (0.41) | HRH4GPR119KCNH2ACACBSLC6A9 | |
| SCHEMBL12457553 | 0.76 | ACACB (0.41) | GPR119KCNH2ACACBSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |