Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2419891 | 0.85 | GRIK1 (0.48) | GRIK1GRIK2KDM4EMAPTALDH1A1 | |
| SCHEMBL2421447 | 0.84 | GRIK1 (0.65) | GRIK1GRIK2KDM4EMAPTALDH1A1 | |
| SCHEMBL17199126 | 0.84 | GRIK1 (0.48) | GRIK1GRIK2TAAR1KDM4EMAPT | |
| SCHEMBL17199125 | 0.83 | GRIK1 (0.45) | GRIK1GRIK2KDM4EMAPTALDH1A1 | |
| SCHEMBL22004132 | 0.82 | ACLY (0.53) | GRIK1GRIK2ACLYCYP11B1CYP11B2 | |
| SCHEMBL2425532 | 0.79 | CYP19A1 (0.52) | GRIK1GRIK2MAPTMEN1KMT2A | |
| SCHEMBL22694522 | 0.77 | GRIK1 (0.49) | GRIK1GRIK2KDM4EMAPTALDH1A1 | |
| SCHEMBL2422990 | 0.77 | KDM4E (0.46) | GRIK1GRIK2KDM4EMAPTALDH1A1 | |
| SCHEMBL17199140 | 0.76 | GRIK1 (0.48) | GRIK1GRIK2KDM4EMAPTALDH1A1 | |
| SCHEMBL17199129 | 0.76 | GRIK1 (0.45) | GRIK1GRIK2KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049480-B1 | 2-ARYLINDOLE DERIVATIVES AS mPGES-1 INHIBITORS | ACRAF (IT) | 2013-10-30 | — | — | EP | disclosed |
| CN-101490000-B | 2-Arylindole derivatives as mPGEs-1 inhibitors | ACRAF | 2012-10-03 | — | — | CN | disclosed |
| US-8017644-B2 | 2-arylindole derivatives as nPGES-1 inhibitors | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2011-09-13 | — | — | US | disclosed |
| US-20090186922-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) | 2009-07-23 | — | — | US | disclosed |
| CN-101490000-A | 2-arylindole derivatives as NPGES-1 inhibitors | ACRAF (IT) | 2009-07-22 | — | — | CN | disclosed |
| EP-2049480-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008006663-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186922-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | PTGES, NAT1, CSNK1G2 | GRIK1 1260/4885GRIK2 773/4885TAAR1 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.