SCHEMBL24199841

SCHEMBL24199841

CCc1ccc(C(=O)c2cc(C)ccc2Br)cc1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.51
HTT P42858 3/20 0.51
NPC1 O15118 2/20 0.51
MAPK1 P28482 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.50
RAB9A P51151 3/20 0.47
SRD5A2 P31213 1/20 0.45
PLK1 P53350 1/20 0.45
ALDH1A1 P00352 4/20 0.44
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
TP53 P04637 1/20 0.42
THRB P10828 1/20 0.42
GAA P10253 1/20 0.41
LMNA P02545 1/20 0.41
F2R P25116 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20157430 0.87 MAPT (0.60) MAPTHTTNPC1MAPK1RAB9A
SCHEMBL13497450 0.84 SRD5A2 (0.47) MAPTHTTNPC1MAPK1SMN1; SMN2
SCHEMBL2240608 0.83 MAPT (0.49) MAPTHTTNPC1SMN1; SMN2RAB9A
SCHEMBL24199843 0.83 MAPT (0.51) MAPTHTTNPC1SMN1; SMN2RAB9A
SCHEMBL20157429 0.81 SRD5A2 (0.49) MAPTHTTNPC1MAPK1SMN1; SMN2
SCHEMBL20157554 0.81 MAPT (0.54) MAPTHTTNPC1MAPK1SMN1; SMN2
SCHEMBL27992485 0.79 MAPT (0.49) MAPTHTTNPC1MAPK1ALDH1A1
SCHEMBL21362751 0.79 ALDH1A1 (0.60) MAPTHTTNPC1SMN1; SMN2RAB9A
SCHEMBL3977886 0.79 MAPT (0.45) MAPTHTTNPC1SMN1; SMN2RAB9A
SCHEMBL21362472 0.79 SRD5A2 (0.43) MAPTHTTNPC1MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3939577-A1 PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATIVE Boehringer Ingelheim International GmbH (DE) 2022-01-19 EP disclosed