Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740237 | 0.80 | NOTUM (0.43) | NOTUMHTR2AHTR2CHTR2BLMNA | |
| SCHEMBL11307322 | 0.80 | NOTUM (0.49) | NOTUMHTR2AHTR2CHTR2BLMNA | |
| SCHEMBL22018747 | 0.80 | NOTUM (0.49) | NOTUMHTR2AHTR2CHTR2BLMNA | |
| SCHEMBL8516304 | 0.80 | NOTUM (0.53) | NOTUMHTR2AHTR2CHTR2BLMNA | |
| SCHEMBL1517961 | 0.76 | NOTUM (0.49) | NOTUMLMNAMEN1MAPTKMT2A | |
| SCHEMBL497420 | 0.76 | NOTUM (0.49) | NOTUMLMNAMEN1MAPTKMT2A | |
| SCHEMBL22292629 | 0.73 | NOTUM (0.53) | NOTUMHTR2AHTR2CHTR2BLMNA | |
| SCHEMBL29172566 | 0.71 | NOTUM (0.48) | NOTUMHTR2AHTR2CHTR2BLMNA | |
| SCHEMBL31672940 | 0.71 | NOTUM (0.55) | NOTUMHTR2AHTR2CHTR2BLMNA | |
| SCHEMBL7733992 | 0.71 | NOTUM (0.55) | NOTUMHTR2AHTR2CHTR2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |