SCHEMBL497420

SCHEMBL497420

COC(=O)C=CN1c2ccccc2CC1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.49
TSHR P16473 2/20 0.46
ALDH1A1 P00352 7/20 0.45
MAPT P10636 2/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
KDM4E B2RXH2 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
GAA P10253 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
LMNA P02545 1/20 0.45
HPGD P15428 1/20 0.45
HSD17B10 Q99714 1/20 0.45
GFER P55789 1/20 0.44
POLB P06746 2/20 0.44
MCL1 Q07820 1/20 0.43
HTT P42858 2/20 0.43
PKM P14618 1/20 0.42
CHRM2 P08172 1/20 0.41
CHRM4 P08173 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1517961 1.00 NOTUM (0.49) NOTUMTSHRALDH1A1MAPTL3MBTL1
SCHEMBL24201529 0.76 NOTUM (0.47) NOTUMALDH1A1MAPTSMN1; SMN2MEN1
SCHEMBL8516304 0.74 NOTUM (0.53) NOTUMALDH1A1MAPTSMN1; SMN2MEN1
SCHEMBL29740237 0.74 NOTUM (0.43) NOTUMALDH1A1MAPTL3MBTL1SMN1; SMN2
SCHEMBL77023 0.73 NOTUM (0.44) NOTUMTSHRALDH1A1MAPTL3MBTL1
SCHEMBL77024 0.73 NOTUM (0.44) NOTUMTSHRALDH1A1MAPTL3MBTL1
SCHEMBL20059520 0.72 NOTUM (0.69) NOTUMTSHRALDH1A1MAPTL3MBTL1
SCHEMBL29923052 0.72 NOTUM (0.69) NOTUMTSHRALDH1A1MAPTL3MBTL1
SCHEMBL28809262 0.71 NOTUM (0.41) NOTUMTSHRALDH1A1MAPTL3MBTL1
SCHEMBL11307322 0.71 NOTUM (0.49) NOTUMALDH1A1MAPTSMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 265 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1582549-B1 Flame retardant resin blends based on polymers derived from 2-hydrocarbyl-3,3-Bis(4-Hydroxyaryl)Phthalimidine monomers SABIC INNOVATIVE PLASTICS IP (NL) 2011-03-09 EP claimed
EP-0108714-A1 Dibenzodioxaphosphepine and dioxaphosphocine processing stabilizers CIBA-GEIGY AG (CH) 1984-05-16 EP claimed
EP-1963399-B1 POLYCYCLIC DIHYDROXY COMPOUNDS AND METHODS FOR PREPARATION SABIC GLOBAL TECHNOLOGIES BV (NL) 2016-07-27 EP disclosed
CN-102099364-B High purity monoalkyltin compounds and uses thereof ARKEMA FRANCE 2015-05-13 CN disclosed
EP-1805130-B1 METHOD FOR THE PREPARATION OF ALIPHATIC CHLOROFORMATES SABIC INNOVATIVE PLASTICS IP (NL) 2015-01-28 EP disclosed
US-8796399-B2 Polyethersulfone compositions with high heat and good impact resistance SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2014-08-05 US disclosed
EP-1805265-B1 METHOD FOR CONTROLLING HAZE IN AN ARTICLE COMPRISING A POLYMER COMPOSITION SABIC INNOVATIVE PLASTICS IP (NL) 2014-04-30 EP disclosed
US-8623971-B2 Polyethersulfone compositions with high heat and good impact resistance SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2014-01-07 US disclosed
US-20130245223-A1 HIGH HEAT POLYETHERSULFONE COMPOSITIONS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2013-09-19 US disclosed
US-8507590-B2 Fluorescent brighteners, methods of preparation thereof, fluorescent brightener compositions, and methods of preparation and uses thereof SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2013-08-13 US disclosed
EP-1581594-B1 POLYCARBONATE MOLDING COMPOSITIONS AND ARTICLES WITH IMPROVED SURFACE AESTHETICS SABIC INNOVATIVE PLASTICS IP (NL) 2013-03-27 EP disclosed
US-3948854-A Salicylic acid hydrazide stabilizers for polymers CIBA-GEIGY CORPORATION (US) 1976-04-06 US disclosed
US-3948852-A Nickel stabilisers for synthetic polymers CIBA-GEIGY CORPORATION (US) 1976-04-06 US disclosed
US-3944632-A Phosphoric acid anilides CIBA-GEIGY CORPORATION (US) 1976-03-16 US disclosed
US-3943098-A 1-Aza-4-thiacyclohexane-4,4-dioxide derivatives and their use as agents protecting against light rays CIBA-GEIGY CORPORATION (US) 1976-03-09 US disclosed
US-3943096-A Use of hydroxyphenylurethanes for stabilising elastomers CIBA-GEIGY CORPORATION (US) 1976-03-09 US disclosed
US-3943106-A POLYESTERS AND POLYAMIDS FROM HYDROXYBENZYLMALONIC ACID DERIVATIVES; STABILIZERS CIBA-GEIGY CORPORATION (US) 1976-03-09 US disclosed
US-3940363-A POLYMERS SANKYO COMPANY LIMITED (JA) 1976-02-24 US disclosed
US-3939175-A STABILIZER CIBA-GEIGY CORPORATION (US) 1976-02-17 US disclosed
US-3937711-A POLYMERIC STABILIZERS, POLYOLEFINS CIBA-GEIGY CORPORATION (US) 1976-02-10 US disclosed