Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.47 |
| ▸ | EIF4E | P06730 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761494 | 0.92 | MKNK1 (0.44) | MKNK1MKNK2EIF4EHTTEGFR | |
| SCHEMBL24201911 | 0.88 | MKNK1 (0.42) | MKNK1MKNK2EIF4ELMNAHTT | |
| SCHEMBL24201968 | 0.88 | MKNK1 (0.42) | MKNK1MKNK2EIF4ELMNAHTT | |
| SCHEMBL23761516 | 0.84 | MKNK1 (0.40) | MKNK1MKNK2EIF4EHTTEGFR | |
| SCHEMBL24201884 | 0.82 | MKNK1 (0.39) | MKNK1MKNK2EIF4EHTTALDH1A1 | |
| SCHEMBL23761514 | 0.81 | ALDH1A1 (0.41) | LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23761323 | 0.80 | MKNK1 (0.48) | MKNK1MKNK2EIF4ELMNA | |
| SCHEMBL23761540 | 0.79 | MKNK1 (0.36) | MKNK1MKNK2EIF4ELMNAHTT | |
| SCHEMBL23761404 | 0.78 | MKNK1 (0.43) | MKNK1MKNK2EIF4EHTTMAPT | |
| SCHEMBL24201824 | 0.78 | MKNK1 (0.45) | MKNK1MKNK2EIF4ELMNAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |