Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | HPGD | P15428 | 3/20 | 0.30 |
| ▸ | GLA | P06280 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761642 | 0.75 | EIF4E (0.35) | KDRMAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL23761530 | 0.69 | NOTUM (0.40) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23761552 | 0.69 | MKNK1 (0.33) | KDRMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL24202017 | 0.69 | NOTUM (0.41) | MAPTTP53KDM4EALDH1A1HPGD | |
| SCHEMBL23761540 | 0.68 | MKNK1 (0.36) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL24202093 | 0.67 | — | — | |
| SCHEMBL10072044 | 0.67 | EGFR (0.44) | KDRMAPTLMNATP53KDM4E | |
| SCHEMBL24202200 | 0.66 | KDR (0.44) | KDRMAPTLMNAALDH1A1HSD17B10 | |
| SCHEMBL23761308 | 0.64 | MKNK1 (0.48) | NOTUM | |
| SCHEMBL10274848 | 0.63 | NOTUM (0.65) | MAPTLMNATP53ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |