Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.35 |
| ▸ | EIF4E | P06730 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CCND1 | P24385 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761492 | 0.90 | MKNK1 (0.45) | NOTUMSRD5A1MKNK1MKNK2EIF4E | |
| SCHEMBL23761530 | 0.84 | NOTUM (0.40) | NOTUMSRD5A1MKNK1MKNK2EIF4E | |
| SCHEMBL24201711 | 0.84 | MKNK1 (0.44) | NOTUMSRD5A1MKNK1MKNK2EIF4E | |
| SCHEMBL24202204 | 0.81 | GPR119 (0.37) | NOTUMSRD5A1MKNK1MKNK2KDM4E | |
| SCHEMBL24202118 | 0.80 | MKNK1 (0.42) | NOTUMSRD5A1MKNK1MKNK2EIF4E | |
| SCHEMBL23761308 | 0.80 | MKNK1 (0.48) | NOTUMSRD5A1MKNK1MKNK2EIF4E | |
| SCHEMBL24201720 | 0.79 | KMT2A (0.40) | NOTUMSRD5A1MKNK1MKNK2EIF4E | |
| SCHEMBL24201658 | 0.76 | SRD5A1 (0.41) | NOTUMSRD5A1MKNK1MKNK2EIF4E | |
| SCHEMBL23761642 | 0.76 | EIF4E (0.35) | SRD5A1MKNK1MKNK2EIF4EKDM4E | |
| SCHEMBL23761414 | 0.74 | SRD5A1 (0.45) | NOTUMSRD5A1MKNK1MKNK2EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939981-A1 | FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS | LifeArc (GB) | 2022-01-19 | — | — | EP | disclosed |