Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | CA7 | P43166 | 3/20 | 0.56 |
| ▸ | CA9 | Q16790 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29970479 | 0.87 | TP53 (0.57) | CA1CA2CA7CA9CA12 | |
| SCHEMBL23409954 | 0.87 | TP53 (0.57) | CA1CA2CA7CA9CA12 | |
| SCHEMBL28412975 | 0.86 | CA1 (0.47) | CA1CA2CA7CA9CA12 | |
| SCHEMBL28412973 | 0.84 | CA1 (0.46) | CA1CA2CA7CA9CA12 | |
| SCHEMBL7124556 | 0.77 | CA1 (0.62) | CA1CA2CA7CA9CA12 | |
| SCHEMBL1225350 | 0.77 | CA1 (0.62) | CA1CA2CA7CA9CA12 | |
| SCHEMBL24446329 | 0.77 | PTPN1 (0.45) | CA1CA2CA7CA9CA12 | |
| SCHEMBL598460 | 0.76 | CA9 (0.68) | CA1CA2CA7CA9CA12 | |
| SCHEMBL1433789 | 0.74 | CA1 (0.52) | CA1CA2CA7CA9CA12 | |
| SCHEMBL31093097 | 0.74 | CA1 (0.52) | CA1CA2CA7CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122029153-A | Aromatic hydrocarbon receptor modulator compound, and preparation method and application thereof | 德明药泰生物技术（深圳）有限公司 | 2026-05-12 | — | — | CN | disclosed |
| US-20250282730-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | Dermavant Sciences GmbH (CH) | 2025-09-11 | — | — | US | disclosed |
| WO-2025082312-A1 | AROMATIC HYDROCARBON RECEPTOR MODULATOR COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 德明药泰生物技术（深圳）有限公司 | 2025-04-24 | — | — | WO | disclosed |
| US-12252471-B2 | Isoquinoline compounds and their use in treating AhR imbalance | Dermavant Sciences GmbH (CH) | 2025-03-18 | — | — | US | disclosed |
| US-20240208910-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | Dermavant Sciences GmbH (CH) | 2024-06-27 | — | — | US | disclosed |
| US-20240208910-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | Dermavant Sciences GmbH (CH) | 2024-06-27 | — | — | US | disclosed |
| US-20240208910-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | Dermavant Sciences GmbH (CH) | 2024-06-27 | — | — | US | disclosed |
| CN-117447402-A | Aromatic hydrocarbon receptor modulator compound, and preparation method and application thereof | 德明药泰生物技术（深圳）有限公司 | 2024-01-26 | — | — | CN | disclosed |
| US-11827605-B2 | Isoquinoline compounds and their use in treating AhR imbalance | Dermavant Sciences GmbH (CH) | 2023-11-28 | — | — | US | disclosed |
| US-11827605-B2 | Isoquinoline compounds and their use in treating AhR imbalance | Dermavant Sciences GmbH (CH) | 2023-11-28 | — | — | US | disclosed |
| US-20230124135-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | Dermavant Sciences GmbH (CH) | 2023-04-20 | — | — | US | disclosed |
| US-11548853-B2 | Isoquinoline compounds and their use in treating AhR imbalance | Dermavant Sciences GmbH (CH) | 2023-01-10 | — | — | US | disclosed |
| US-11548853-B2 | Isoquinoline compounds and their use in treating AhR imbalance | Dermavant Sciences GmbH (CH) | 2023-01-10 | — | — | US | disclosed |
| US-20220153703-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | Dermavant Sciences GmbH (CH) | 2022-05-19 | — | — | US | disclosed |
| US-20220153703-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | Dermavant Sciences GmbH (CH) | 2022-05-19 | — | — | US | disclosed |
| US-11267788-B2 | Isoquinoline compounds and their use in treating AhR imbalance | Dermavant Sciences GmbH (CH) | 2022-03-08 | — | — | US | disclosed |
| US-11267788-B2 | Isoquinoline compounds and their use in treating AhR imbalance | Dermavant Sciences GmbH (CH) | 2022-03-08 | — | — | US | disclosed |
| US-20220017468-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | Dermavant Sciences GmbH (CH) | 2022-01-20 | — | — | US | disclosed |
| US-20220017468-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | Dermavant Sciences GmbH (CH) | 2022-01-20 | — | — | US | disclosed |
| WO-2022015423-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | Dermavant Sciences GmbH (CH) | 2022-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230124135-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | AHR, ARNT, HRH1 | CA1 3913/4885CA2 2298/4885CA7 3267/4885 |
| US-12252471-B2 | Isoquinoline compounds and their use in treating AhR imbalance | AHR, ARNT, HRH1 | CA1 3913/4885CA2 2298/4885CA7 3267/4885 |
| US-20250282730-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | AHR, ARNT, HRH1 | CA1 3913/4885CA2 2298/4885CA7 3267/4885 |
| US-20220017468-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | AHR, ARNT, HRH1 | CA1 3913/4885CA2 2298/4885CA7 3267/4885 |
| US-20220153703-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | AHR, ARNT, HRH1 | CA1 3913/4885CA2 2298/4885CA7 3267/4885 |
| US-11827605-B2 | Isoquinoline compounds and their use in treating AhR imbalance | AHR, ARNT, HRH1 | CA1 3913/4885CA2 2298/4885CA7 3267/4885 |
| US-11548853-B2 | Isoquinoline compounds and their use in treating AhR imbalance | AHR, ARNT, HRH1 | CA1 3913/4885CA2 2298/4885CA7 3267/4885 |
| US-20240208910-A1 | ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE | AHR, ARNT, HRH1 | CA1 3913/4885CA2 2298/4885CA7 3267/4885 |
| US-11267788-B2 | Isoquinoline compounds and their use in treating AhR imbalance | AHR, ARNT, HRH1 | CA1 3913/4885CA2 2298/4885CA7 3267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.