Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.45 |
| ▸ | MTOR | P42345 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30411894 | 1.00 | PIK3CA (0.45) | PIK3CAMTORMAP4K4ATRADORA2A | |
| SCHEMBL23623107 | 0.85 | PIK3CA (0.48) | PIK3CAMTORMAP4K4TLR7KDR | |
| SCHEMBL23623068 | 0.84 | PIK3CA (0.45) | PIK3CAMTORMAP4K4MAPTALDH1A1 | |
| SCHEMBL23623610 | 0.80 | POLB (0.38) | MTORADORA2AMAPTALDH1A1LMNA | |
| SCHEMBL14070979 | 0.80 | SMN1; SMN2 (0.50) | MAPTKDM4EALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL29046099 | 0.79 | ALDH1A1 (0.47) | PIK3CAMTORATRMAPTKDM4E | |
| SCHEMBL30412634 | 0.79 | ALDH1A1 (0.47) | PIK3CAMTORATRMAPTKDM4E | |
| SCHEMBL23622940 | 0.77 | SCN10A (0.39) | PIK3CAMTORATRMAPTALDH1A1 | |
| SCHEMBL16391106 | 0.76 | MAPT (0.54) | MAP4K4ADORA2AMAPTKDM4EALDH1A1 | |
| SCHEMBL24215560 | 0.76 | CASP1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116528862-A | Compounds and compositions for the treatment of diseases associated with STING activity | 艾福姆德尤股份有限公司 | 2023-08-01 | — | — | CN | disclosed |
| EP-4182028-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM Due, Inc. (US) | 2023-05-24 | — | — | EP | disclosed |
| WO-2022015957-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM DUE, INC. (US) | 2022-01-20 | — | — | WO | disclosed |
| WO-2022015957-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM DUE, INC. (US) | 2022-01-20 | — | — | WO | disclosed |