Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.54 |
| ▸ | CNR1 | P21554 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15043679 | 0.90 | SLC6A4 (0.59) | SLC6A4SLC6A3SLC6A2CNR1CNR2 | |
| SCHEMBL15043625 | 0.87 | SLC6A4 (0.55) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL9399121 | 0.85 | CNR2 (0.57) | SLC6A4SLC6A3SLC6A2CNR1CNR2 | |
| SCHEMBL15043618 | 0.84 | SLC6A4 (0.59) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL12002388 | 0.82 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL10604569 | 0.82 | SLC6A4 (0.51) | SLC6A4SLC6A3SLC6A2CNR1CNR2 | |
| SCHEMBL5153687 | 0.81 | SLC6A3 (0.57) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL5308752 | 0.81 | SLC6A3 (0.57) | SLC6A4SLC6A3SLC6A2CYP3A4ALOX15 | |
| SCHEMBL5310266 | 0.81 | SLC6A4 (0.60) | SLC6A4SLC6A3SLC6A2 | |
| Hydrochloric Acid SCHEMBL5308783 | 0.81 | SLC6A4 (0.60) | SLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814352-A | ANTIDEPRESSANT CYCLOBUTYL BENZYLAMINE | THE BOOTS COMPANY PLC (GB) | 1989-03-21 | — | — | US | disclosed |
| US-4806570-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4767790-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | disclosed |
| US-4746680-A | ANTIDEPRESSANTS | THE BOOTS COMPANY P.L.C. (GB) | 1988-05-24 | — | — | US | disclosed |