SCHEMBL24225614

SCHEMBL24225614

Cc1cc(C=O)cnc1N1CCC(F)(F)CC1

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A3 P47895 2/20 0.37
ALDH1A1 P00352 1/20 0.37
SCN10A Q9Y5Y9 9/20 0.36
SIGMAR1 Q99720 1/20 0.34
PIK3CA P42336 1/20 0.34
MTOR P42345 1/20 0.34
FLT3 P36888 1/20 0.34
KIF18A Q8NI77 3/20 0.33
PDE10A Q9Y233 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24225601 0.83 SCN10A (0.35) SCN10ASIGMAR1PIK3CAMTORFLT3
SCHEMBL24225609 0.81 PDE10A (0.35) SCN10ASIGMAR1PIK3CAMTORPDE10A
SCHEMBL22322264 0.81 ALDH1A3 (0.40) ALDH1A3ALDH1A1
SCHEMBL25215747 0.79 MEN1 (0.39) ALDH1A1
SCHEMBL25929683 0.78 SCN10A (0.43) SCN10ASIGMAR1PIK3CAMTORFLT3
SCHEMBL22803865 0.78 TRPV1 (0.42) SCN10ASIGMAR1PIK3CAMTORFLT3
SCHEMBL30412557 0.78 TRPV1 (0.42) SCN10ASIGMAR1PIK3CAMTORFLT3
SCHEMBL29287745 0.77 ALDH1A3 (0.37) ALDH1A3ALDH1A1PDE10A
SCHEMBL15351824 0.77 SCN10A (0.36) SCN10ASIGMAR1PIK3CAMTORFLT3
SCHEMBL15350774 0.76 PTGER4 (0.48) SCN10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220024906-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2022-01-27 US disclosed
US-20220024906-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2022-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220024906-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 ALDH1A3 4465/4885ALDH1A1 4654/4885SCN10A 2166/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.