Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.58 |
| ▸ | ATF4 | P18848 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30578689 | 1.00 | RAB9A (0.58) | RAB9ANPC1SMYD3ATF4HDAC3 | |
| SCHEMBL30578714 | 1.00 | RAB9A (0.58) | RAB9ANPC1SMYD3ATF4HDAC3 | |
| Trifluoroacetic Acid SCHEMBL21050114 | 0.92 | RAB9A (0.51) | RAB9ANPC1SMYD3ATF4HDAC3 | |
| Trifluoroacetic Acid SCHEMBL21050116 | 0.92 | RAB9A (0.51) | RAB9ANPC1SMYD3ATF4HDAC3 | |
| SCHEMBL21050136 | 0.90 | RAB9A (0.58) | RAB9ANPC1SMYD3ATF4HDAC3 | |
| SCHEMBL24225638 | 0.88 | RAB9A (0.73) | RAB9ANPC1ATF4HDAC3HDAC4 | |
| SCHEMBL17209555 | 0.88 | RAB9A (0.73) | RAB9ANPC1ATF4HDAC3HDAC4 | |
| SCHEMBL24997328 | 0.88 | RAB9A (0.56) | RAB9ANPC1SMYD3ATF4HDAC3 | |
| SCHEMBL24998315 | 0.88 | RAB9A (0.56) | RAB9ANPC1SMYD3ATF4HDAC3 | |
| SCHEMBL30053417 | 0.88 | RAB9A (0.56) | RAB9ANPC1SMYD3ATF4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047589-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2023-02-16 | — | — | US | disclosed |
| US-11230542-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2022-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230542-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | RAB9A 3893/4885NPC1 2384/4885SMYD3 3785/4885 |
| US-20230047589-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | RAB9A 3893/4885NPC1 2384/4885SMYD3 3785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.