SCHEMBL2422609

SCHEMBL2422609

O=S(=O)(Nc1nc2ccccc2nc1OCc1ccc2ccccc2c1)c1cccc(Cl)c1Cl

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR4 P51679 19/20 0.58
PTGDR2 Q9Y5Y4 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2425241 0.91 CCR4 (0.55) CCR4PTGDR2
SCHEMBL2422198 0.89 MEN1 (0.47) CCR4PTGDR2
SCHEMBL2422056 0.89 CCR4 (0.61) CCR4
SCHEMBL12282384 0.87 CCR4 (0.76) CCR4PTGDR2
SCHEMBL2421003 0.87 CCR4 (0.56) CCR4
SCHEMBL2419196 0.87 EDNRA (0.46) CCR4PTGDR2
SCHEMBL2419910 0.86 MEN1 (0.50) CCR4PTGDR2
SCHEMBL2429470 0.86 MEN1 (0.53) CCR4PTGDR2
SCHEMBL2422888 0.86 CCR4 (0.61) CCR4
SCHEMBL2421587 0.85 CCR4 (0.57) CCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2374802-B1 KYNURENINE PRODUCTION INHIBITOR KYOWA HAKKO KIRIN CO LTD (JP) 2014-04-23 EP disclosed
US-8673908-B2 Kynurenine production inhibitor KYOWA HAKKO KIRIN CO., LTD. (JP) 2014-03-18 US disclosed
EP-2374802-A1 KYNURENINE PRODUCTION INHIBITOR Kyowa Hakko Kirin Co., Ltd. (JP) 2011-10-12 EP disclosed
US-20110237584-A1 KYNURENINE PRODUCTION INHIBITOR KYOWA KIRIN CO., LTD. (JP) 2011-09-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110237584-A1 KYNURENINE PRODUCTION INHIBITOR KYNU, KMO, IDO1 CCR4 3284/4885PTGDR2 1085/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.