Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.57 |
| ▸ | NMT1 | P30419 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14624276 | 0.88 | HRH1 (0.56) | HRH1NMT1 | |
| SCHEMBL2422739 | 0.79 | SLC5A7 (0.46) | HRH1SLC5A7BRS3 | |
| SCHEMBL22365344 | 0.78 | HRH1 (0.58) | HRH1NMT1 | |
| SCHEMBL14624277 | 0.77 | HRH1 (0.59) | HRH1NMT1 | |
| Trifluoroacetic Acid SCHEMBL2426715 | 0.77 | CACNA1B (0.44) | — | |
| SCHEMBL12735792 | 0.74 | HRH1 (0.62) | HRH1NMT1BRS3 | |
| Trifluoroacetic Acid SCHEMBL4715454 | 0.73 | SLC6A2 (0.52) | HRH1 | |
| SCHEMBL21481540 | 0.73 | HRH1 (0.54) | HRH1NMT1 | |
| Trifluoroacetic Acid SCHEMBL30619008 | 0.72 | CHRNB2 (0.63) | HRH1 | |
| Trifluoroacetic Acid SCHEMBL26600428 | 0.72 | CHRNB2 (0.63) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012995-B1 | Pharmaceutically active sulfonamide derivatives | MERCK SERONO SA (CH) | 2011-09-06 | — | — | US | disclosed |
| EP-1218374-B1 | PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2005-11-16 | — | — | EP | disclosed |
| EP-1218374-A1 | PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001023378-A1 | PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-05 | — | — | WO | disclosed |