SCHEMBL24229481

SCHEMBL24229481

c1cnc2ccc(-c3ccc(Nc4ccc(-c5ccc6ncccc6c5)cc4)cc3)cc2c1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.75
POLB P06746 3/20 0.75
RAB9A P51151 2/20 0.75
DYRK1A Q13627 1/20 0.60
MAPT P10636 2/20 0.54
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
MCL1 Q07820 1/20 0.51
ALDH1A1 P00352 4/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
KDM4E B2RXH2 1/20 0.50
TP53 P04637 1/20 0.50
HSP90AA1 P07900 1/20 0.50
HSP90AB1 P08238 1/20 0.50
TSHR P16473 1/20 0.50
CASP1 P29466 1/20 0.50
HTT P42858 1/20 0.50
ATM Q13315 1/20 0.50
HSD17B10 Q99714 1/20 0.50
GSK3B P49841 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31451575 1.00 NPC1 (0.75) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL6748149 0.93 NPC1 (0.63) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL2791886 0.88 ABCB1 (0.61) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL30743 0.87 NPC1 (1.00) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL29757180 0.87 NPC1 (1.00) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL2164236 0.86 NPC1 (0.70) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL30592751 0.83 NPC1 (0.84) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL12075055 0.83 NPC1 (0.84) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL443618 0.83 NPC1 (0.84) NPC1POLBRAB9ADYRK1AMAPT
SCHEMBL1011248 0.82 PABPC1 (0.59) NPC1POLBRAB9AMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022025648-A1 NOVEL COMPOUND FOR CAPPING LAYER AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME 주식회사 동진쎄미켐 2022-02-03 WO disclosed