Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 4/20 | 0.37 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.37 |
| ▸ | FUCA1 | P04066 | 4/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GLB1 | P16278 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278929 | 1.00 | GBA1 (0.37) | GBA1MAN1B1FUCA1GLAGAA | |
| SCHEMBL3278934 | 1.00 | GBA1 (0.37) | GBA1MAN1B1FUCA1GLAGAA | |
| SCHEMBL16817909 | 0.86 | SLC6A1 (0.33) | — | |
| SCHEMBL16817867 | 0.86 | SLC6A1 (0.33) | — | |
| SCHEMBL2244738 | 0.86 | SLC6A1 (0.33) | — | |
| SCHEMBL16817902 | 0.86 | SLC6A1 (0.33) | — | |
| SCHEMBL2686886 | 0.84 | SLC6A1 (0.34) | GBA1 | |
| SCHEMBL2242364 | 0.84 | SLC6A1 (0.34) | GBA1 | |
| SCHEMBL2181109 | 0.84 | SLC6A1 (0.34) | GBA1 | |
| SCHEMBL2242371 | 0.84 | SLC6A1 (0.34) | GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150051185-A1 | Chemical Compounds 251 | ASTRAZENECA AB (SE) | 2015-02-19 | — | — | US | disclosed |
| US-8901307-B2 | Chemical compounds 251 | ASTRAZENECA AB (SE) | 2014-12-02 | — | — | US | disclosed |
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2011-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | PIM1, PIM3, PIM2 | GBA1 2734/4885MAN1B1 3630/4885FUCA1 2465/4885 |
| US-20150051185-A1 | Chemical Compounds 251 | PIM1, PIM3, PIM2 | GBA1 2883/4885MAN1B1 3722/4885FUCA1 2501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.