Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 4/20 | 0.33 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.33 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.33 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRE | P78334 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2244738 | 1.00 | SLC6A1 (0.33) | SLC6A1SLC6A11SLC6A13GABRA5GABRB2 | |
| SCHEMBL16817902 | 1.00 | SLC6A1 (0.33) | SLC6A1SLC6A11SLC6A13GABRA5GABRB2 | |
| SCHEMBL16817909 | 1.00 | SLC6A1 (0.33) | SLC6A1SLC6A11SLC6A13GABRA5GABRB2 | |
| SCHEMBL2686885 | 0.88 | SLC6A1 (0.34) | SLC6A1SLC6A11SLC6A13GABRA5GABRB2 | |
| SCHEMBL2242364 | 0.88 | SLC6A1 (0.34) | SLC6A1SLC6A11SLC6A13GABRA5GABRB2 | |
| SCHEMBL2242371 | 0.88 | SLC6A1 (0.34) | SLC6A1SLC6A11SLC6A13GABRA5GABRB2 | |
| SCHEMBL2686886 | 0.88 | SLC6A1 (0.34) | SLC6A1SLC6A11SLC6A13GABRA5GABRB2 | |
| SCHEMBL2181109 | 0.88 | SLC6A1 (0.34) | SLC6A1SLC6A11SLC6A13GABRA5GABRB2 | |
| SCHEMBL2423080 | 0.86 | GBA1 (0.37) | — | |
| SCHEMBL3278934 | 0.86 | GBA1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9518054-B2 | 2-(azaindol-2-yl) benz imidazoles as PAD4 inhibitors | GLAXO GROUP LIMITED (GB) | 2016-12-13 | — | — | US | disclosed |
| US-20160009716-A1 | 2 - (AZAINDOL-2-YL) BENZ IMIDAZOLES AS PAD4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2016-01-14 | — | — | US | disclosed |
| US-9127003-B2 | 2-(azaindol-2-yl)benzimidazoles as PAD4 inhibitors | GLAXO GROUP LIMITED (GB) | 2015-09-08 | — | — | US | disclosed |
| US-20150175600-A1 | 2-(AZAINDOL-2-YL)BENZIMIDAZOLES AS PAD4 INHIBITORS | Glaxo Group Limited a corporation | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009716-A1 | 2 - (AZAINDOL-2-YL) BENZ IMIDAZOLES AS PAD4 INHIBITORS | PADI1, PADI4, PADI2 | SLC6A1 3048/4885SLC6A11 3542/4885SLC6A13 2882/4885 |
| US-20150175600-A1 | 2-(AZAINDOL-2-YL)BENZIMIDAZOLES AS PAD4 INHIBITORS | PADI1, PADI4, PADI2 | SLC6A1 3079/4885SLC6A11 3602/4885SLC6A13 2782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.