Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.68 |
| ▸ | BLM | P54132 | 6/20 | 0.64 |
| ▸ | WRN | Q14191 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 5/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19911109 | 0.81 | SRC (1.00) | SRCBRAFABL1CDK1CDK2 | |
| SCHEMBL24449241 | 0.81 | ABL1 (0.60) | SRCBRAFABL1CDK1CDK2 | |
| SCHEMBL24449225 | 0.80 | SRC (0.61) | SRCABL1CDK1CDK2CDK8 | |
| SCHEMBL24449270 | 0.79 | SRC (0.60) | SRCBRAFABL1CDK1CDK2 | |
| SCHEMBL29602870 | 0.78 | BLM (1.00) | BLMWRN | |
| SCHEMBL20659647 | 0.78 | BLM (1.00) | BLMWRN | |
| SCHEMBL24233232 | 0.77 | BLM (1.00) | BLMWRN | |
| SCHEMBL24449284 | 0.77 | SRC (0.68) | SRCBRAFABL1CDK1CDK2 | |
| SCHEMBL19317695 | 0.77 | ABL1 (0.72) | SRCABL1CDK1CDK2CDK8 | |
| SCHEMBL20912769 | 0.76 | KIT (0.71) | SRCBRAFABL1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022026823-A1 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2022-02-03 | — | — | WO | disclosed |