Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.67 |
| ▸ | GRB2 | P62993 | 1/20 | 0.57 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | XIAP | P98170 | 1/20 | 0.49 |
| ▸ | PTPRC | P08575 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | TPH1 | P17752 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876107 | 1.00 | PTPN1 (0.67) | PTPN1GRB2SLC7A5PTGS1ALPI | |
| SCHEMBL26076516 | 0.88 | PTPN1 (0.57) | PTPN1GRB2SLC7A5PTGS1ALPI | |
| SCHEMBL14450441 | 0.86 | PTPN1 (0.50) | PTPN1GRB2KDM4EALDH1A1LMNA | |
| SCHEMBL14450445 | 0.86 | PTPN1 (0.48) | PTPN1GRB2SMN1; SMN2 | |
| SCHEMBL7244978 | 0.83 | PTPN1 (0.46) | PTPN1ITGB3ITGA2BALDH1A1SMN1; SMN2 | |
| SCHEMBL7244973 | 0.83 | PTPN1 (0.46) | PTPN1ITGB3ITGA2BALDH1A1SMN1; SMN2 | |
| SCHEMBL14450417 | 0.81 | PTPN1 (0.47) | PTPN1GRB2SLC7A5PTGS1ALPI | |
| SCHEMBL14450450 | 0.81 | PTPN1 (0.45) | PTPN1 | |
| Phosphonodifluoromethyl Phenylalanine SCHEMBL9545904 | 0.81 | PTPN1 (1.00) | PTPN1GRB2SLC7A5PTGS1ALPI | |
| Phosphonodifluoromethyl Phenylalanine SCHEMBL2517439 | 0.81 | PTPN1 (1.00) | PTPN1GRB2SLC7A5PTGS1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303625-A1 | CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION | RA PHARMACEUTICALS, INC. (US) | 2023-09-28 | — | — | US | disclosed |
| US-11530244-B2 | Cyclic polypeptides for PCSK9 inhibition | MERCK SHARP & DOHME LLC (US) | 2022-12-20 | — | — | US | disclosed |
| US-20210284694-A1 | CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION | MERCK SHARP & DOHME LLC | 2021-09-16 | — | — | US | disclosed |
| US-9399653-B2 | Methods and systems for preparing irreversible inhibitors of protein tyrosine phosphatases | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2016-07-26 | — | — | US | disclosed |
| US-20130165333-A1 | Methods and Systems for Preparing Irreversible Inhibitors of Protein Tyrosine Phosphatases | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2013-06-27 | — | — | US | disclosed |
| WO-2011106898-A1 | METHODS AND SYSTEMS FOR PREPARING IRREVERSIBLE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210284694-A1 | CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION | PCSK9, LDLR, PCSK7 | PTPN1 682/4885GRB2 1230/4885SLC7A5 3660/4885 |
| US-20230303625-A1 | CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION | PCSK9, LDLR, PCSK7 | PTPN1 682/4885GRB2 1230/4885SLC7A5 3660/4885 |
| US-11530244-B2 | Cyclic polypeptides for PCSK9 inhibition | PCSK9, LDLR, PCSK7 | PTPN1 682/4885GRB2 1230/4885SLC7A5 3660/4885 |
| US-20130165333-A1 | Methods and Systems for Preparing Irreversible Inhibitors of Protein Tyrosine Phosphatases | SRMS, PTMS, PPM1A | PTPN1 102/4885GRB2 286/4885SLC7A5 1134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.