Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 7/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3425213 | 0.81 | SMN1; SMN2 (0.46) | PRKDCCYP1A2CYP3A4CYP2C19KDM4E | |
| SCHEMBL12324179 | 0.80 | PRKDC (0.62) | PRKDCPDE10ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL28407489 | 0.77 | EGFR (0.76) | EGFRKCNH2MAPTMAPK10 | |
| SCHEMBL30997551 | 0.75 | SMN1; SMN2 (0.46) | PRKDCEGFRCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7205056 | 0.74 | PRKDC (0.56) | PRKDCCYP1A2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL16235435 | 0.74 | CYP2C19 (0.46) | PRKDCPDE10ACYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL2419958 | 0.74 | PRKDC (0.67) | PRKDCKCNH2 | |
| SCHEMBL2423187 | 0.73 | IP6K1 (0.70) | ALDH1A1 | |
| SCHEMBL29416616 | 0.73 | PDE4A (0.47) | EGFRKDM4EALDH1A1MAPT | |
| SCHEMBL1011889 | 0.73 | PDE4A (0.47) | EGFRKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547664-B1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2016-05-04 | — | — | EP | disclosed |
| US-9126952-B2 | Morpholinylquinazolines | MERCK PATENT GMBH (DE) | 2015-09-08 | — | — | US | disclosed |
| EP-2547664-A1 | MORPHOLINYLQUINAZOLINES | Merck Patent GmbH (DE) | 2013-01-23 | — | — | EP | disclosed |
| US-20130012489-A1 | Morpholinylquinazolines | MERCK PATENT GMBH (DE) | 2013-01-10 | — | — | US | disclosed |
| WO-2011113512-A1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011113512-A1 | MORPHOLINYLQUINAZOLINES | MERCK PATENT GMBH (DE) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012489-A1 | Morpholinylquinazolines | LATS2, TNK2, SKP1 | PRKDC 2343/4885EGFR 669/4885PDE10A 2667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.