Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.76 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.61 |
| ▸ | FLT4 | P35916 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.61 |
| ▸ | CIT | O14578 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.61 |
| ▸ | STK17B | O94768 | 1/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28411490 | 0.88 | EGFR (0.60) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL27923390 | 0.87 | EGFR (0.67) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL8565015 | 0.84 | EGFR (0.66) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL27923376 | 0.82 | EGFR (0.61) | EGFRERBB2KDREPHB4ERBB4 | |
| SCHEMBL28409239 | 0.81 | EGFR (0.63) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL29577309 | 0.81 | EGFR (0.92) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL28935220 | 0.81 | EGFR (0.92) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL28403915 | 0.81 | EGFR (0.74) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL28181387 | 0.80 | EGFR (0.63) | EGFRERBB2FLT4KDREPHB4 | |
| SCHEMBL28713534 | 0.80 | EGFR (0.92) | EGFRERBB2FLT4KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107200715-B | Quinazoline derivative and application thereof in preparation of antitumor drugs | 陕西师范大学 | 2020-05-29 | — | — | CN | disclosed |