Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 5/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6426384 | 0.79 | CYP1A2 (0.59) | CYP1A2TSHRTP53SMN1; SMN2ADORA2A | |
| SCHEMBL26348815 | 0.78 | CYP1A2 (0.54) | CYP1A2TSHRTP53SMN1; SMN2ADORA2A | |
| SCHEMBL18521260 | 0.76 | CYP1A2 (0.49) | CYP1A2TSHRTP53SMN1; SMN2ADORA2A | |
| SCHEMBL6363954 | 0.75 | ADORA2A (0.60) | CYP1A2TSHRTP53SMN1; SMN2ADORA2A | |
| SCHEMBL23228237 | 0.75 | CYP1A2 (0.72) | CYP1A2TSHRTP53SMN1; SMN2ADORA2A | |
| SCHEMBL12194505 | 0.75 | PI4KA (0.60) | CYP1A2TSHRTP53SMN1; SMN2ADORA2A | |
| SCHEMBL320849 | 0.75 | ADORA2A (0.41) | CYP1A2ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL22399500 | 0.74 | ADORA2A (0.42) | CYP1A2TSHRADORA2AADORA1PI4KA | |
| SCHEMBL22326711 | 0.73 | CYP1A2 (0.49) | CYP1A2TSHRTP53SMN1; SMN2ADORA2A | |
| SCHEMBL667204 | 0.72 | ADORA2A (0.62) | ADORA2AADORA1PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220175811-A1 | STABLE FORMULATIONS OF CYCLIC DINUCLEOTIDE STING AGONIST COMPOUNDS AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. (US) | 2022-06-09 | — | — | US | disclosed |
| US-20220033435-A1 | Cyclic Di-Nucleotide Compounds as STING Agonists | MERCK SHARP & DOHME CORP. (US) | 2022-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220033435-A1 | Cyclic Di-Nucleotide Compounds as STING Agonists | STING1, CGAS, IFNAR1 | CYP1A2 1793/4885TSHR 2059/4885TP53 4413/4885 |
| US-20220175811-A1 | STABLE FORMULATIONS OF CYCLIC DINUCLEOTIDE STING AGONIST COMPOUNDS AND METHODS OF USE THEREOF | STING1, CGAS, IRF3 | CYP1A2 4630/4885TSHR 3172/4885TP53 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.