Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 2/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13299192 | 0.80 | ALDH1A1 (0.53) | KCNJ6KCNJ5KCNJ3ALDH1A1KDM4E | |
| SCHEMBL12462755 | 0.77 | KCNJ6 (0.44) | KCNJ6KCNJ5KCNJ3ALDH1A1KDM4E | |
| SCHEMBL14621515 | 0.76 | KCNJ6 (0.40) | KCNJ6KCNJ5KCNJ3ALDH1A1KDM4E | |
| SCHEMBL12859230 | 0.76 | KCNJ6 (0.40) | KCNJ6KCNJ5KCNJ3ALDH1A1KDM4E | |
| SCHEMBL24239348 | 0.75 | — | — | |
| SCHEMBL14653933 | 0.74 | KCNJ6 (0.39) | KCNJ6KCNJ5KCNJ3ALDH1A1KDM4E | |
| SCHEMBL14654030 | 0.74 | KCNJ6 (0.42) | KCNJ6KCNJ5KCNJ3ALDH1A1KDM4E | |
| SCHEMBL17321052 | 0.74 | KCNJ6 (0.39) | KCNJ6KCNJ5KCNJ3ALDH1A1KDM4E | |
| SCHEMBL20320331 | 0.73 | KCNJ6 (0.39) | KCNJ6KCNJ5KCNJ3ALDH1A1KDM4E | |
| SCHEMBL2516272 | 0.72 | KCNJ6 (0.46) | KCNJ6KCNJ5KCNJ3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858930-B2 | Fused bicyclic RAF inhibitors and methods for use thereof | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2024-01-02 | — | — | US | disclosed |
| US-20220033398-A1 | FUSED BICYCLIC RAF INHIBITORS AND METHODS FOR USE THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2022-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220033398-A1 | FUSED BICYCLIC RAF INHIBITORS AND METHODS FOR USE THEREOF | BRAF, RAF1, NRAS | KCNJ6 4438/4885KCNJ5 4413/4885KCNJ3 4243/4885 |
| US-11858930-B2 | Fused bicyclic RAF inhibitors and methods for use thereof | BRAF, RAF1, NRAS | KCNJ6 4438/4885KCNJ5 4413/4885KCNJ3 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.