Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2425863 | 0.85 | HRH3 (0.33) | MAPTHTTNPSR1HRH3KCNH2 | |
| SCHEMBL222647 | 0.84 | KMT2A (0.41) | HTTHRH3KCNH2RAB9AKMT2A | |
| SCHEMBL2429279 | 0.81 | HRH3 (0.33) | MAPTTSHRHTTNPSR1HRH3 | |
| SCHEMBL2421851 | 0.81 | HRH3 (0.35) | MAPTHRH3KCNH2RAB9ANPC1 | |
| Cyclohexane SCHEMBL2428515 | 0.80 | HRH3 (0.40) | HRH3KCNH2RAB9ANPC1CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL445482 | 0.79 | HRH3 (0.38) | MAPTHTTHRH3KCNH2RAB9A | |
| SCHEMBL223649 | 0.77 | KCNH2 (0.46) | MAPTTSHRHTTNPSR1HRH3 | |
| SCHEMBL2428638 | 0.76 | HRH3 (0.38) | MAPTHRH3KCNH2RAB9ANPC1 | |
| SCHEMBL223654 | 0.76 | KMT2A (0.46) | HRH3KCNH2RAB9AKMT2AATM | |
| SCHEMBL2422227 | 0.76 | GRM5 (0.40) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212283-B1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2011-09-21 | — | — | EP | claimed |