Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexane SCHEMBL2428515 | 0.93 | HRH3 (0.40) | HRH3KCNH2CYP3A4RAB9ANPC1 | |
| SCHEMBL220849 | 0.86 | HRH3 (0.38) | HRH3KCNH2CYP3A4RAB9A | |
| SCHEMBL223649 | 0.84 | KCNH2 (0.46) | HRH3KCNH2RAB9AMAPT | |
| SCHEMBL223654 | 0.83 | KMT2A (0.46) | HRH3KCNH2RAB9A | |
| Trifluoroacetic Acid SCHEMBL222396 | 0.83 | HRH3 (0.35) | HRH3KCNH2RAB9A | |
| SCHEMBL222631 | 0.81 | RAB9A (0.47) | HRH3CYP3A4RAB9ANPC1MAPT | |
| SCHEMBL2421213 | 0.81 | KMT2A (0.44) | HRH3CYP3A4RAB9ANPC1POLB | |
| Trifluoroacetic Acid SCHEMBL444415 | 0.80 | KCNH2 (0.41) | HRH3KCNH2RAB9AMAPT | |
| SCHEMBL2423319 | 0.80 | KDM4E (0.56) | CYP3A4POLBMAPT | |
| Trifluoroacetic Acid SCHEMBL223098 | 0.79 | KMT2A (0.41) | HRH3KCNH2RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212283-B1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2011-09-21 | — | — | EP | claimed |