Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 8/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 8/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
| ▸ | CCNH | P51946 | 2/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424299 | 1.00 | CCNK (0.47) | CCNKCDK12HCAR3JAK3CYP3A4 | |
| SCHEMBL28555866 | 0.86 | CCNK (0.61) | CCNKCDK12HCAR3JAK3CCNA2 | |
| SCHEMBL28555865 | 0.86 | CCNK (0.61) | CCNKCDK12HCAR3JAK3CCNA2 | |
| SCHEMBL29240904 | 0.85 | HCAR3 (0.44) | CCNKCDK12HCAR3JAK3 | |
| SCHEMBL29240908 | 0.85 | HCAR3 (0.44) | CCNKCDK12HCAR3JAK3 | |
| SCHEMBL28552999 | 0.85 | CCNK (0.60) | CCNKCDK12HCAR3JAK3 | |
| SCHEMBL28508298 | 0.85 | ALDH1A1 (0.46) | CCNKCDK12HCAR3JAK3 | |
| SCHEMBL28559024 | 0.85 | CCNK (0.60) | CCNKCDK12HCAR3JAK3 | |
| SCHEMBL28559025 | 0.85 | CCNK (0.60) | CCNKCDK12HCAR3JAK3 | |
| SCHEMBL28552998 | 0.85 | CCNK (0.60) | CCNKCDK12HCAR3JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367817-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Via Pharmaceuticals, Inc. (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010065310-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | VIA PHARMACEUTICALS, INC (US) | 2010-06-10 | — | — | WO | disclosed |