Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.58 |
| ▸ | BTK | Q06187 | 7/20 | 0.58 |
| ▸ | TTK | P33981 | 2/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PAK4 | O96013 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | LTK | P29376 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561059 | 0.76 | JAK3 (0.42) | JAK3BTKPTK2JAK2TBK1 | |
| SCHEMBL24243327 | 0.75 | JAK3 (0.58) | JAK3BTKJAK2TBK1IKBKE | |
| SCHEMBL22497050 | 0.74 | JAK3 (1.00) | JAK3BTK | |
| SCHEMBL22497048 | 0.74 | JAK3 (1.00) | JAK3BTK | |
| SCHEMBL24243290 | 0.73 | JAK3 (0.59) | JAK3BTKJAK2KDRAURKB | |
| SCHEMBL19020771 | 0.72 | AURKA (0.44) | JAK3BTKTTKPTK2JAK2 | |
| SCHEMBL24243283 | 0.71 | JAK3 (0.52) | JAK3BTKTTKPTK2JAK2 | |
| SCHEMBL24243371 | 0.71 | JAK3 (0.52) | JAK3BTKPTK2 | |
| SCHEMBL8178868 | 0.71 | TAS2R8 (0.43) | JAK3JAK2TBK1IKBKEMAP4K4 | |
| Hydrochloric Acid SCHEMBL3257525 | 0.70 | TAS2R8 (0.43) | JAK3JAK2TBK1IKBKEMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3950691-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR | Daewoong Pharmaceutical Co., Ltd. (KR) | 2022-02-09 | — | — | EP | disclosed |