Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.59 |
| ▸ | BTK | Q06187 | 15/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24243168 | 0.80 | JAK3 (0.55) | JAK3BTKEGFR | |
| SCHEMBL24243327 | 0.79 | JAK3 (0.58) | JAK3BTKKDRAURKBJAK2 | |
| SCHEMBL24243287 | 0.78 | JAK3 (0.59) | JAK3BTKKDRAURKBEGFR | |
| SCHEMBL24243303 | 0.76 | JAK3 (0.54) | JAK3BTKAURKBJAK2MAPK1 | |
| SCHEMBL22497018 | 0.76 | JAK3 (1.00) | JAK3BTKEGFR | |
| SCHEMBL22497020 | 0.76 | JAK3 (1.00) | JAK3BTKEGFR | |
| SCHEMBL4561059 | 0.73 | JAK3 (0.42) | JAK3BTKKDRAURKBJAK2 | |
| SCHEMBL24243285 | 0.73 | JAK3 (0.58) | JAK3BTKKDRAURKBJAK2 | |
| SCHEMBL31219538 | 0.72 | JAK3 (0.61) | JAK3BTKEGFR | |
| SCHEMBL24243330 | 0.71 | JAK3 (0.61) | JAK3BTKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3950691-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR | Daewoong Pharmaceutical Co., Ltd. (KR) | 2022-02-09 | — | — | EP | disclosed |