Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | ITK | Q08881 | 11/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TTK | P33981 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22513976 | 0.89 | BTK (0.55) | JAK3BTKITKTTKAURKA | |
| SCHEMBL24243385 | 0.84 | BTK (0.58) | JAK3BTKITKTTKAURKA | |
| SCHEMBL24243330 | 0.83 | JAK3 (0.61) | JAK3BTKJAK2 | |
| SCHEMBL24243309 | 0.79 | TTK (0.67) | JAK3BTKTP53MAPTMAPK1 | |
| SCHEMBL17150871 | 0.78 | TP53 (0.53) | JAK3TP53MAPTMAPK1TTK | |
| SCHEMBL16344213 | 0.76 | PTGS2 (0.72) | TP53MAPTMAPK1AURKAAURKB | |
| SCHEMBL24243290 | 0.76 | JAK3 (0.59) | JAK3BTKMAPK1AURKBJAK2 | |
| SCHEMBL4417817 | 0.76 | MAPT (0.67) | TP53MAPTMAPK1AURKAAURKB | |
| SCHEMBL17908123 | 0.74 | MAPT (0.61) | TP53MAPTMAPK1AURKAAURKB | |
| SCHEMBL14694266 | 0.74 | SYK (0.58) | TP53MAPTMAPK1AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3950691-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR | Daewoong Pharmaceutical Co., Ltd. (KR) | 2022-02-09 | — | — | EP | disclosed |