Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 6/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 11/20 | 0.56 |
| ▸ | KDM5A | P29375 | 8/20 | 0.56 |
| ▸ | KDM5B | Q9UGL1 | 8/20 | 0.44 |
| ▸ | KDM4A | O75164 | 3/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24244136 | 0.88 | PHF8 (0.61) | PHF8KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL24244244 | 0.81 | PHF8 (0.58) | PHF8KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL20979041 | 0.80 | PHF8 (0.59) | PHF8KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL24244130 | 0.75 | KDM5A (0.66) | PHF8KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL16034039 | 0.75 | PHF8 (0.63) | PHF8KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL24244200 | 0.74 | PHF8 (0.51) | PHF8KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL19383295 | 0.73 | PHF8 (0.56) | PHF8KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL16033406 | 0.72 | KDM4C (1.00) | PHF8KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL17604562 | 0.71 | PHF8 (0.60) | PHF8KDM4CKDM5AKDM5BKDM4A | |
| SCHEMBL17686567 | 0.71 | KDM4C (0.73) | PHF8KDM4CKDM5AKDM5BKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2022-02-09 | — | — | EP | disclosed |