Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 4/20 | 0.66 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.66 |
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.60 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.60 |
| ▸ | KDM5A | P29375 | 4/20 | 0.60 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | KDM4A | O75164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KDM5C | P41229 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604583 | 0.82 | PHF8 (0.68) | PHF8KDM2BKDM4CKDM5BKDM5A | |
| SCHEMBL18579666 | 0.77 | KDM4C (0.67) | PHF8KDM2BKDM4CKDM5BKDM5A | |
| SCHEMBL16034040 | 0.75 | KDM4C (1.00) | PHF8KDM2BKDM4CKDM5BKDM5A | |
| SCHEMBL19383509 | 0.74 | PHF8 (0.57) | PHF8KDM2BKDM4CKDM5BKDM5A | |
| SCHEMBL19383318 | 0.70 | PHF8 (0.53) | PHF8KDM2BKDM4CKDM5BKDM5A | |
| SCHEMBL29377387 | 0.69 | KDM5B (0.57) | PHF8KDM2BKDM4CKDM5BKDM5A | |
| SCHEMBL19383013 | 0.67 | PHF8 (0.69) | PHF8KDM2BKDM4CKDM5BKDM5A | |
| SCHEMBL24003746 | 0.66 | KDM4E (0.46) | KDM4CKDM4AKDM4EKDM5CKDM2A | |
| SCHEMBL19708394 | 0.65 | BRD4 (0.44) | BRD4 | |
| SCHEMBL14850277 | 0.65 | IDO1 (0.45) | KDM4CBRD4KDM4AKDM4EKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2022-02-09 | — | — | EP | disclosed |