Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2425807 | 0.69 | TSHR (0.42) | ALDH1A1HPGDLMNA | |
| SCHEMBL5648212 | 0.68 | FAAH (0.54) | ALDH1A1CA2CHKAPOLBKMT2A | |
| SCHEMBL5270457 | 0.67 | — | — | |
| SCHEMBL3947407 | 0.67 | ALDH1A1 (0.93) | ALDH1A1CA2CHKAPOLBKMT2A | |
| SCHEMBL3948090 | 0.67 | ALDH1A1 (0.93) | ALDH1A1CA2CHKAPOLBKMT2A | |
| SCHEMBL733597 | 0.67 | ALDH1A1 (0.93) | ALDH1A1CA2CHKAPOLBKMT2A | |
| SCHEMBL3948862 | 0.67 | ALDH1A1 (0.93) | ALDH1A1CA2CHKAPOLBKMT2A | |
| SCHEMBL2323473 | 0.67 | ALDH1A1 (0.93) | ALDH1A1CA2CHKAPOLBKMT2A | |
| SCHEMBL3947402 | 0.67 | ALDH1A1 (0.93) | ALDH1A1CA2CHKAPOLBKMT2A | |
| SCHEMBL3948084 | 0.67 | ALDH1A1 (0.93) | ALDH1A1CA2CHKAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |