Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.40 |
| ▸ | CDK2 | P24941 | 6/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22494637 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9ACCNE1CDK2 | |
| SCHEMBL22494638 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9ACCNE1CDK2 | |
| SCHEMBL20877549 | 0.71 | CCNE1 (0.50) | SMN1; SMN2CCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL22494667 | 0.71 | CCNE1 (0.50) | SMN1; SMN2CCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL20877548 | 0.71 | CCNE1 (0.50) | SMN1; SMN2CCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL20877325 | 0.70 | UCHL1 (0.45) | SMN1; SMN2RAB9ACCNE1CDK2CDK5 | |
| SCHEMBL20877327 | 0.70 | UCHL1 (0.45) | SMN1; SMN2RAB9ACCNE1CDK2CDK5 | |
| SCHEMBL20239934 | 0.69 | USP30 (0.38) | SMN1; SMN2NPC1RAB9ACCNE1CDK2 | |
| SCHEMBL22494774 | 0.68 | CCNE1 (0.48) | SMN1; SMN2RAB9ACCNE1CDK2CDK5 | |
| SCHEMBL24514543 | 0.68 | CCNE1 (0.48) | SMN1; SMN2RAB9ACCNE1CDK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11247987-B2 | Inhibiting ubiquitin specific peptidase 30 | FORMA THERAPEUTICS, INC. (US) | 2022-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11247987-B2 | Inhibiting ubiquitin specific peptidase 30 | USP30, UCHL1, UCHL3 | SMN1; SMN2 181/4885NPC1 2635/4885RAB9A 1020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.