Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | CSK | P41240 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17437914 | 0.89 | ROCK2 (0.39) | EIF4A3ROCK2PDE4BNAMPTSPR | |
| SCHEMBL19127285 | 0.83 | MGLL (0.39) | EIF4A3ROCK2PDE4BSPR | |
| SCHEMBL17454359 | 0.81 | ROCK2 (0.40) | EIF4A3ROCK2LCKCSK | |
| SCHEMBL23888943 | 0.80 | IRAK4 (0.36) | EIF4A3ROCK2PDE4BLCKCSK | |
| SCHEMBL23888960 | 0.80 | NAMPT (0.43) | EIF4A3ROCK2NAMPT | |
| SCHEMBL17437924 | 0.80 | ROCK2 (0.42) | ROCK2 | |
| SCHEMBL17437899 | 0.80 | KAT2B (0.39) | ROCK2PDE4B | |
| SCHEMBL17437999 | 0.79 | CYP1A2 (0.37) | EIF4A3ROCK2PDE4BSPR | |
| SCHEMBL17437998 | 0.79 | ROCK2 (0.35) | EIF4A3ROCK2PDE4BSPR | |
| SCHEMBL17438075 | 0.78 | ROCK2 (0.38) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954681-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | Bristol-Myers Squibb Company (US) | 2022-02-16 | — | — | EP | disclosed |