Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 6/20 | 0.44 |
| ▸ | USP25 | Q9UHP3 | 4/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25800838 | 0.86 | CHRM4 (0.39) | USP28USP25CHRM4POLBTP53 | |
| SCHEMBL22645075 | 0.76 | USP25 (0.81) | USP28USP25 | |
| SCHEMBL24595753 | 0.74 | USP28 (0.49) | USP28USP25TP53 | |
| SCHEMBL24248137 | 0.70 | KDM4E (0.40) | USP28USP25CHRM4KDM4EALDH1A1 | |
| SCHEMBL24248138 | 0.69 | SMN1; SMN2 (0.41) | CHRM4KDM4EALDH1A1POLBTP53 | |
| SCHEMBL25800841 | 0.69 | NPC1 (0.40) | USP28USP25CHRM4KDM4EALDH1A1 | |
| SCHEMBL21457816 | 0.68 | USP28 (0.47) | USP28USP25KDM4EALDH1A1IKBKB | |
| SCHEMBL22645007 | 0.66 | KDM4E (0.47) | USP28USP25CHRM4KDM4EALDH1A1 | |
| SCHEMBL24248117 | 0.65 | IKBKB (0.49) | CHRM4KDM4EALDH1A1POLBTP53 | |
| SCHEMBL17920678 | 0.65 | CHRM4 (0.63) | CHRM4KDM4EALDH1A1POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954694-A1 | UBIQUITIN-SPECIFIC PROTEASE INHIBITORS, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Chaser Therapeutics, Inc. (CN) | 2022-02-16 | — | — | EP | disclosed |