Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24248117 | 0.87 | IKBKB (0.49) | KDM4EALDH1A1SMN1; SMN2HPGDHTT | |
| SCHEMBL24248137 | 0.87 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2HPGDHTT | |
| SCHEMBL20732017 | 0.79 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2HPGDHTT | |
| SCHEMBL22645006 | 0.75 | LIMK1 (0.52) | KDM4EALDH1A1SMN1; SMN2HPGDHTT | |
| SCHEMBL24248138 | 0.71 | SMN1; SMN2 (0.41) | KDM4EALDH1A1SMN1; SMN2HPGDGAA | |
| SCHEMBL20731112 | 0.70 | IKBKB (0.60) | KDM4EALDH1A1SMN1; SMN2HPGDHTT | |
| SCHEMBL19211014 | 0.70 | USP28 (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDHTT | |
| SCHEMBL21457814 | 0.70 | KDM4E (0.63) | KDM4EALDH1A1SMN1; SMN2HPGDGAA | |
| SCHEMBL24248139 | 0.68 | ALDH1A1 (0.39) | KDM4EALDH1A1SMN1; SMN2HPGDHTT | |
| SCHEMBL24248129 | 0.66 | USP28 (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213118-A1 | UBIQUITIN-SPECIFIC PROTEASE INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOFF | CHASER THERAPEUTICS, INC. (CN) | 2022-07-07 | — | — | US | disclosed |
| EP-3954694-A1 | UBIQUITIN-SPECIFIC PROTEASE INHIBITORS, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Chaser Therapeutics, Inc. (CN) | 2022-02-16 | — | — | EP | disclosed |
| WO-2020224652-A1 | UBIQUITIN-SPECIFIC PROTEASE INHIBITORS, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 北京普济远成生物科技有限公司 | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213118-A1 | UBIQUITIN-SPECIFIC PROTEASE INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOFF | USP28, USP25, USP24 | KDM4E 2500/4885ALDH1A1 1156/4885SMN1; SMN2 3242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.