Amfenac

Amfenac

SCHEMBL24249

Nc1c(CC(=O)O)cccc1C(=O)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ABCB11 O95342 1/20 0.78
LMNA P02545 1/20 0.78
PTGS1 P23219 1/20 0.78
ADORA1 P30542 1/20 0.78
PTGS2 P35354 1/20 0.78
GAA P10253 1/20 0.53
MAPT P10636 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Amfenac SCHEMBL30777846 1.00 ABCB11 (0.78) ABCB11LMNAPTGS1ADORA1PTGS2
Amfenac SCHEMBL42390 0.98 ABCB11 (0.76) ABCB11LMNAPTGS1ADORA1PTGS2
Amfenac SCHEMBL11168965 0.98 ABCB11 (0.76) ABCB11LMNAPTGS1ADORA1PTGS2
Amfenac SCHEMBL11726346 0.98 ABCB11 (0.76) ABCB11LMNAPTGS1ADORA1PTGS2
Amfenac SCHEMBL9747734 0.98 ABCB11 (0.76) ABCB11LMNAPTGS1ADORA1PTGS2
Amfenac SCHEMBL9747027 0.98 ABCB11 (0.76) ABCB11LMNAPTGS1ADORA1PTGS2
Amfenac SCHEMBL9998546 0.98 ABCB11 (0.76) ABCB11LMNAPTGS1ADORA1PTGS2
Amfenac SCHEMBL11467022 0.97 ABCB11 (0.74) ABCB11LMNAPTGS1ADORA1PTGS2
Amfenac SCHEMBL10824627 0.97 ABCB11 (0.74) ABCB11LMNAPTGS1ADORA1PTGS2
Amfenac SCHEMBL10589034 0.97 ABCB11 (0.74) ABCB11LMNAPTGS1ADORA1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6150 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260000741-A1 METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE ACERAGEN INC (US) 2026-01-01 US claimed
EP-4628080-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Jeil Pharmaceutical Co., Ltd. (KR) 2025-10-08 EP claimed
US-12364703-B2 Homogeneous ophthalmic composition ADCOX, JAMES M., III 2025-07-22 US claimed
US-20250064760-A1 INTRACANALICULAR INSERT COMPRISING A NON-STEROIDAL ANTI-INFLAMMATORY AGENT OCULAR THERAPEUTIX, INC. 2025-02-27 US claimed
US-12226549-B2 Synergistically cooperative compositions useful for soft tissue augmentation, drug delivery and related fields ALTERGON S.A. (CH) 2025-02-18 US claimed
EP-4470565-A1 METHOD FOR PREVENTING OR TREATING DISEASE OR DISORDER ASSOCIATED WITH ANTINEOPLASTIC AGENT OnQuality Pharmaceuticals China Ltd. (CN) 2024-12-04 EP claimed
EP-4460285-A1 INTRACANALICULAR INSERT COMPRISING A NON-STEROIDAL ANTI-INFLAMMATORY AGENT Ocular Therapeutix, Inc. (US) 2024-11-13 EP claimed
CN-118742291-A Intratubular insert comprising non-steroidal anti-inflammatory agent 视尔普斯眼科公司 2024-10-01 CN claimed
CN-118340907-A Polymer conjugates comprising bioactive agents 波利艾克蒂瓦有限公司 2024-07-16 CN claimed
WO-2024117797-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF 제일약품 주식회사 2024-06-06 WO claimed
EP-0569411-A1 ACYLAMINO-ALKYLIDEN-HYDROXY-BISPHOSPHONIC ACIDS USEFUL IN THE THERAPY OF OSTEOARTICULAR DISEASES. GENTILI IST SPA (IT) 1993-11-18 EP claimed
EP-0537313-A1 ARYLALKYL ESTERS OF 4,5-DIHYDROXY-9,10-DIHYDRO-9,10-DIOXO-2-ANTHRACENECARBOXYLIC ACID HAVING THERAPEUTICAL ACTIVITY. GENTILI IST SPA (IT) 1993-04-21 EP claimed
WO-1992019584-A1 ARYLALKYL ESTERS OF 4,5-DIHYDROXY-9,10-DIHYDRO-9,10-DIOXO-2-ANTHRACENECARBOXYLIC ACID HAVING THERAPEUTICAL ACTIVITY ISTITUTO GENTILI S.P.A. (IT) 1992-11-12 WO claimed
WO-1992013864-A1 ACYLAMINO-ALKYLIDEN-HYDROXY-BISPHOSPHONIC ACIDS USEFUL IN THE THERAPY OF OSTEOARTICULAR DISEASES ISTITUTO GENTILI S.P.A. (IT) 1992-08-20 WO claimed
EP-0466650-A2 Improvements in non-steroidal anti-inflammatory therapy WARNER-LAMBERT COMPANY (US) 1992-01-15 EP claimed
EP-0221753-B1 TRANSDERMAL TREATMENT FOR PAIN AND INFLAMMATION WITH 2-AMINO-3-AROYLBENZENEACETIC ACIDS, SALTS AND ESTERS A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) 1992-01-08 EP claimed
US-4683242-A Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters A. H. ROBINS COMPANY, INCORPORATED (US) 1987-07-28 US claimed
EP-0221753-A2 Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) 1987-05-13 EP claimed
US-4221716-A Intermediate and process for the preparation of 7-acylindolin-2-ones A. H. ROBINS COMPANY, INC. (US) 1980-09-09 US claimed
US-4045576-A ANTI-INFLAMMATORY METHODS USING 2-AMINO-3-(5- AND 6-)BENZOYLPHENYLACETIC ACIDS, ESTERS AND METAL SALTS THEREOF AND THE COMPOUNDS A. H. ROBINS COMPANY, INCORPORATED (US) 1977-08-30 US claimed