Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | DDX3X | O00571 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2685334 | 0.84 | GPR142 (0.60) | KDM4EMAPTHPGDHDAC1HDAC2 | |
| SCHEMBL2685328 | 0.84 | GPR142 (0.60) | KDM4EMAPTHPGDHDAC1HDAC2 | |
| SCHEMBL6665555 | 0.80 | KMT2A (0.65) | RAB9AKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL30452307 | 0.80 | KMT2A (0.65) | RAB9AKMT2AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2685986 | 0.78 | GPR142 (0.67) | RAB9ANPC1KDM4ESMN1; SMN2XIAP | |
| SCHEMBL7039856 | 0.77 | HDAC8 (0.66) | RAB9ANPC1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4949860 | 0.76 | NPC1 (0.52) | RAB9ANPC1KMT2AMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL1600794 | 0.76 | ROCK1 (0.56) | — | |
| SCHEMBL19302571 | 0.76 | MEN1 (0.55) | RAB9ANPC1KMT2AMEN1KDM4E | |
| SCHEMBL3009223 | 0.76 | CIT (0.53) | CSNK2A2CSNK2A1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2891649-B1 | Prolylhydroxylase inhibitors and methods of use | UNIV CORNELL (US) | 2018-04-11 | — | — | EP | disclosed |
| US-9505741-B2 | Prolylhydroxylase inhibitors and methods of use | CORNELL UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| EP-2891649-A1 | Prolylhydroxylase inhibitors and methods of use | Cornell University (US) | 2015-07-08 | — | — | EP | disclosed |
| US-20130023528-A1 | PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE | CORNELL UNIVERSITY (US) | 2013-01-24 | — | — | US | disclosed |
| EP-2536709-A2 | PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE | Cornell University (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011106226-A2 | PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE | CORNELL UNIVERSITY (US) | 2011-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023528-A1 | PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE | EGLN3, HIF1AN, EGLN2 | RAB9A 4030/4885NPC1 1890/4885KMT2A 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.