Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 8/20 | 0.54 |
| ▸ | TLR2 | O60603 | 1/20 | 0.50 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.50 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.42 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.42 |
| ▸ | ABAT | P80404 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11230561 | 0.85 | ALDH1A1 (0.55) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL18525712 | 0.84 | CYP1A2 (0.44) | ERN1TLR2TLR1TLR6CA1 | |
| SCHEMBL8501456 | 0.81 | KDM4E (0.52) | CA1CA2ALDH1A1KDM4ETSHR | |
| SCHEMBL11229197 | 0.81 | ERN1 (0.54) | ERN1TLR2TLR1TLR6CA1 | |
| SCHEMBL1298117 | 0.80 | GRIN2D (0.53) | ERN1CA1CA2TRIM24TRIM33 | |
| SCHEMBL4935526 | 0.79 | ALDH1A1 (0.53) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL4059355 | 0.78 | ALDH1A1 (0.61) | ERN1TLR2TLR1TLR6ALDH1A1 | |
| SCHEMBL8955962 | 0.76 | KDM4E (0.56) | CA1CA2ALDH1A1KDM4ETSHR | |
| SCHEMBL29620158 | 0.75 | ALDH1A1 (0.77) | CA1CA2ALDH1A1KDM4EHPGD | |
| SCHEMBL8206713 | 0.75 | ALDH1A1 (0.77) | CA1CA2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536685-B1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS | PFIZER (US) | 2022-02-16 | — | — | EP | disclosed |