Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24251774 | 0.84 | IAPP (0.43) | IAPPMAPTSMN1; SMN2MAPK1PTGER4 | |
| SCHEMBL24251715 | 0.76 | CCNA2 (0.32) | CCNA2CDK2GRM1HTTKDM4E | |
| SCHEMBL30899979 | 0.75 | IAPP (0.43) | IAPPMAPTSMN1; SMN2MAPK1PTGER4 | |
| SCHEMBL24496622 | 0.75 | CCNA2 (0.32) | CCNA2CDK2GRM1 | |
| SCHEMBL20680456 | 0.75 | CCNA2 (0.34) | MAPTCCNA2CDK2CYP1A2CYP2C9 | |
| SCHEMBL24996463 | 0.72 | LMNA (0.34) | CCNA2CDK2 | |
| SCHEMBL13961326 | 0.71 | MAPK1 (0.44) | IAPPMAPTSMN1; SMN2MAPK1PTGER4 | |
| SCHEMBL31193217 | 0.71 | LCK (0.46) | IAPPMAPTSMN1; SMN2MAPK1PTGER4 | |
| SCHEMBL17417521 | 0.71 | LCK (0.46) | IAPPMAPTSMN1; SMN2MAPK1PTGER4 | |
| SCHEMBL3113398 | 0.69 | ATR (0.43) | IAPPMAPTSMN1; SMN2MAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115836064-A | Triazine derivative with EGFR (epidermal growth factor receptor) inhibitory activity and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-03-21 | — | — | CN | disclosed |
| WO-2022033455-A1 | TRIAZINE DERIVATIVE HAVING EGFR INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |