SCHEMBL24251926

SCHEMBL24251926

CC#Cc1c(F)cc2sc(C3CC3)nc2c1F

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30082439 0.83 ALDH1A1 (0.36) ALDH1A1LMNA
SCHEMBL24251927 0.83 ALDH1A1 (0.36) ALDH1A1LMNA
SCHEMBL26411989 0.72 RET (0.36) ALDH1A1LMNA
SCHEMBL26412097 0.72 RET (0.33) ALDH1A1LMNA
SCHEMBL24251866 0.72 ALDH1A1 (0.36) ALDH1A1LMNA
SCHEMBL30082389 0.72 ALDH1A1 (0.36) ALDH1A1LMNA
SCHEMBL24251867 0.70 RAB9A (0.51) ALDH1A1LMNA
SCHEMBL30082420 0.70 RAB9A (0.51) ALDH1A1LMNA
SCHEMBL24251906 0.62 NPC1 (0.38) ALDH1A1LMNA
SCHEMBL24251956 0.62 ALDH1A1 (0.40) ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4169922-A1 FGFR AND MUTATION INHIBITOR THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF Abbisko Therapeutics Co., Ltd. (CN) 2023-04-26 EP disclosed
WO-2022033532-A1 FGFR AND MUTATION INHIBITOR THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海和誉生物医药科技有限公司 2022-02-17 WO disclosed