SCHEMBL24252100

SCHEMBL24252100

Cc1ccc(CCc2c(Cl)ccc(F)c2-c2c(OC(=O)C(C)C)c(C)nn(C)c2=O)cc1

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.33
LMNA P02545 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
CYP1A2 P05177 2/20 0.33
CYP2C19 P33261 2/20 0.33
POLB P06746 1/20 0.32
P2RX7 Q99572 1/20 0.31
P2RX3 P56373 3/20 0.31
TDP1 Q9NUW8 1/20 0.31
PTGES O14684 1/20 0.31
GALR3 O60755 1/20 0.30
CYP3A4 P08684 1/20 0.30
HTT P42858 1/20 0.30
SLC22A12 Q96S37 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22085498 0.95 POLB (0.35) SMN1; SMN2LMNAMEN1KMT2ACYP1A2
SCHEMBL22031827 0.95 CYP1A2 (0.39) SMN1; SMN2LMNACYP1A2CYP2C19POLB
SCHEMBL22031798 0.91 CYP1A2 (0.36) SMN1; SMN2LMNACYP1A2CYP2C19POLB
SCHEMBL30484557 0.91 CYP1A2 (0.36) SMN1; SMN2LMNACYP1A2CYP2C19POLB
SCHEMBL22085491 0.91 POLB (0.35) LMNACYP1A2CYP2C19POLBP2RX7
SCHEMBL22085494 0.91 LMNA (0.34) SMN1; SMN2LMNAMEN1KMT2ACYP1A2
SCHEMBL22906269 0.91 CCR3 (0.33) SMN1; SMN2LMNACYP1A2CYP2C19P2RX7
SCHEMBL30388958 0.90 CYP1A2 (0.33) SMN1; SMN2LMNAMEN1KMT2ACYP1A2
SCHEMBL30389030 0.90 HTR2A (0.31) CYP1A2CYP2C19POLB
SCHEMBL25184309 0.90 SMN1; SMN2 (0.33) SMN1; SMN2LMNAMEN1KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12162840-B2 Herbicidal compositions SYNGENTA CROP PROTECTION AG (CH) 2024-12-10 US claimed
US-20230301300-A1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2023-09-28 US claimed
US-20220119353-A1 Herbicidal Compositions SYNGENTA PARTICIPATIONS AG (CH) 2022-04-21 US claimed
US-20230301300-A1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2023-09-28 US disclosed
US-20230301300-A1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2023-09-28 US disclosed
US-20220119353-A1 Herbicidal Compositions SYNGENTA PARTICIPATIONS AG (CH) 2022-04-21 US disclosed
WO-2022033893-A1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2022-02-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12162840-B2 Herbicidal compositions DDT, HPD, PNPO SMN1; SMN2 4583/4885LMNA 2951/4885MEN1 4581/4885
US-20230301300-A1 HERBICIDAL COMPOSITIONS GMDS, DDT, AADAC SMN1; SMN2 4432/4885LMNA 2970/4885MEN1 4394/4885
US-20220119353-A1 Herbicidal Compositions DDT, HPD, PNPO SMN1; SMN2 4583/4885LMNA 2951/4885MEN1 4581/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.