Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 11/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GIPR | P48546 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2422363 | 0.90 | GCGR (0.42) | GCGRCYP1A2MAPTMAPK1KDM4E | |
| SCHEMBL2421582 | 0.88 | MAPT (0.44) | GCGRCYP1A2MAPTMAPK1KDM4E | |
| SCHEMBL2426189 | 0.85 | GCGR (0.50) | GCGRCYP3A4CYP2C8CYP2C9GIPR | |
| SCHEMBL14445954 | 0.85 | GCGR (0.42) | GCGRCYP1A2MAPTMAPK1KDM4E | |
| SCHEMBL2424700 | 0.84 | CYP1A2 (0.40) | GCGRCYP1A2MAPTMAPK1KDM4E | |
| SCHEMBL4682127 | 0.83 | GCGR (0.53) | GCGRMAPTGAARECQLHDAC1 | |
| SCHEMBL5023766 | 0.82 | KCNJ6 (0.40) | HDAC1ADORA3SCN9A | |
| SCHEMBL4677624 | 0.82 | GCGR (0.41) | GCGRCYP1A2MAPTMAPK1KDM4E | |
| SCHEMBL508428 | 0.81 | MAPT (0.45) | GCGRCYP1A2MAPTMAPK1KDM4E | |
| SCHEMBL14445949 | 0.81 | GCGR (0.51) | GCGRMAPTHDAC1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237640-A1 | PYRAZOLE PHENYL DERIVATIVES | ACKERMANN JEAN | 2011-09-29 | — | — | US | disclosed |
| US-20100035953-A1 | Pyrazole Phenyl Derivatives | ACKERMANN JEAN | 2010-02-11 | — | — | US | disclosed |
| EP-1742923-B1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | disclosed |
| EP-1725546-B1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2008-10-08 | — | — | EP | disclosed |
| US-7265149-B2 | Indolyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1742923-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-01-17 | — | — | EP | disclosed |
| EP-1725546-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005105754-A1 | PYRAZOLE PHENYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | disclosed |
| US-20050245589-A1 | Pyrazole phenyl derivatives | HOFFMANN-LA ROCHE INC. | 2005-11-03 | — | — | US | disclosed |
| WO-2005085235-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-15 | — | — | WO | disclosed |
| US-20050203160-A1 | Indolyl derivatives | HOFFMANN-LA ROCHE INC. | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035953-A1 | Pyrazole Phenyl Derivatives | PPARD, PPARG, PPARA | GCGR 27/4885CYP1A2 94/4885MAPT 4133/4885 |
| US-20050245589-A1 | Pyrazole phenyl derivatives | PPARD, PPARG, PPARA | GCGR 27/4885CYP1A2 94/4885MAPT 4133/4885 |
| US-20110237640-A1 | PYRAZOLE PHENYL DERIVATIVES | PPARD, PPARG, PPARA | GCGR 27/4885CYP1A2 94/4885MAPT 4133/4885 |
| US-20050203160-A1 | Indolyl derivatives | PPARD, PPARA, PPARG | GCGR 84/4885CYP1A2 184/4885MAPT 3559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.