Sugi Predict

Sugi Predict / Compounds / SCHEMBL24252687

SCHEMBL24252687

SCHEMBL24252687

COc1ccc(B(O)O)cc1-c1cc(OC)c2ccnnc2c1

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ PDE10A Q9Y233 11/20 0.38
▸ SYK P43405 1/20 0.36
▸ KDR P35968 2/20 0.34
▸ ERN1 O75460 2/20 0.33
▸ PDE3B Q13370 1/20 0.33
▸ PDE3A Q14432 1/20 0.33
▸ DHFR P00374 1/20 0.32
▸ ALOX15 P16050 1/20 0.32
▸ LRRK2 Q5S007 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30467566 1.00 PDE10A (0.38) PDE10ASYKKDRERN1PDE3B
SCHEMBL26771382 0.91 PDE10A (0.38) PDE10ASYKERN1DHFRALOX15
SCHEMBL30451279 0.82 DHFR (0.37) PDE10AKDRDHFRLRRK2
SCHEMBL24252379 0.82 DHFR (0.37) PDE10AKDRDHFRLRRK2
SCHEMBL30451967 0.81 ERN1 (0.46) PDE10ASYKERN1
SCHEMBL24252959 0.81 ERN1 (0.46) PDE10ASYKERN1
SCHEMBL24252302 0.78 PDE10A (0.42) PDE10ADHFRLRRK2
SCHEMBL30451917 0.78 PDE10A (0.42) PDE10ADHFRLRRK2
SCHEMBL24252260 0.77 PDE10A (0.46) PDE10ADHFRLRRK2
SCHEMBL30467809 0.77 PDE10A (0.46) PDE10ADHFRLRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON INC (US) 2026-03-12 — — US disclosed
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
CN-116947903-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-10-27 — — CN disclosed
CN-116261564-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-06-13 — — CN disclosed
EP-4185592-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2023-05-31 — — EP disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 PDE10A 1950/4885SYK 1943/4885KDR 3397/4885
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 PDE10A 1950/4885SYK 1943/4885KDR 3397/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 PDE10A 1950/4885SYK 1943/4885KDR 3397/4885
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFH, CFB, C5 PDE10A 2158/4885SYK 1143/4885KDR 2338/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.