Sugi Predict

Sugi Predict / Compounds / SCHEMBL24252842

SCHEMBL24252842

SCHEMBL24252842

COc1ccc(CNc2cnnc3cc(-c4cc(Cl)c(CCOC5CCCCO5)cc4OC)ccc23)c(OC)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ CYP1A2 P05177 13/20 0.36
▸ CYP3A4 P08684 13/20 0.36
▸ CYP2C19 P33261 12/20 0.36
▸ TSHR P16473 11/20 0.36
▸ ALDH1A1 P00352 9/20 0.36
▸ CYP2C9 P11712 8/20 0.36
▸ CLK4 Q9HAZ1 7/20 0.36
▸ LMNA P02545 7/20 0.36
▸ HSD17B10 Q99714 5/20 0.36
▸ CYP2D6 P10635 11/20 0.35
▸ MAPK1 P28482 5/20 0.35
▸ TDP1 Q9NUW8 2/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ PDE9A O76083 2/20 0.35
▸ KDM4C Q9H3R0 1/20 0.35
▸ HIF1A Q16665 5/20 0.34
▸ USP2 O75604 6/20 0.34
▸ GLA P06280 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30467747 1.00 NPC1 (0.43) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL29015286 0.98 NPC1 (0.40) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL30451465 0.87 CYP1A2 (0.37) CYP1A2CYP3A4CYP2C19TSHRALDH1A1
SCHEMBL29015646 0.87 CYP1A2 (0.37) CYP1A2CYP3A4CYP2C19TSHRALDH1A1
SCHEMBL24252333 0.85 NPC1 (0.41) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL30467624 0.85 NPC1 (0.41) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL24252477 0.82 CYP1A2 (0.42) CYP1A2CYP3A4CYP2C19TSHRALDH1A1
SCHEMBL30452368 0.82 CYP1A2 (0.42) CYP1A2CYP3A4CYP2C19TSHRALDH1A1
SCHEMBL25299300 0.80 PDE9A (0.35) CYP1A2CYP3A4CYP2C19TSHRALDH1A1
SCHEMBL30462730 0.80 PDE9A (0.35) CYP1A2CYP3A4CYP2C19TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
EP-4185592-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2023-05-31 — — EP disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 NPC1 460/4885RAB9A 2013/4885CYP1A2 2977/4885
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 NPC1 460/4885RAB9A 2013/4885CYP1A2 2977/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 NPC1 460/4885RAB9A 2013/4885CYP1A2 2977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.