Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2422171 | 0.90 | MMP8 (0.52) | PNMTMAPK1MAPTMMP8PDE3B | |
| SCHEMBL10544621 | 0.87 | MMP8 (0.54) | PNMTMAPK1MAPTMMP8PDE3B | |
| SCHEMBL2422785 | 0.86 | MMP8 (0.49) | PNMTMAPK1MAPTMMP8PDE3B | |
| SCHEMBL15261865 | 0.86 | MMP8 (0.41) | MAPK1MAPTMMP8ALDH1A1TP53 | |
| SCHEMBL901770 | 0.84 | MMP8 (0.47) | PNMTMAPK1MAPTMMP8PDE3B | |
| SCHEMBL5751162 | 0.83 | PNMT (0.54) | PNMTMAPTALDH1A1PPARGPPARA | |
| SCHEMBL2425273 | 0.83 | MMP8 (0.46) | PNMTMAPK1MAPTMMP8PDE3B | |
| SCHEMBL15261621 | 0.82 | SMN1; SMN2 (0.51) | PNMTMAPK1MAPTMMP8ALDH1A1 | |
| SCHEMBL2422444 | 0.82 | PNMT (0.44) | PNMTMAPK1MAPTMMP8PDE3B | |
| SCHEMBL2428821 | 0.82 | MDM2 (0.51) | PNMTMAPK1MAPTMMP8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |