⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30424524 | 1.00 | — | — | |
| SCHEMBL30423637 | 0.86 | TPH1 (0.33) | — | |
| SCHEMBL30424565 | 0.86 | TPH1 (0.33) | — | |
| SCHEMBL24253857 | 0.86 | TPH1 (0.33) | — | |
| SCHEMBL24253750 | 0.86 | TPH1 (0.33) | — | |
| SCHEMBL24253867 | 0.84 | — | — | |
| SCHEMBL30423918 | 0.84 | EP300 (0.30) | — | |
| SCHEMBL24253860 | 0.84 | EP300 (0.30) | — | |
| SCHEMBL24253559 | 0.81 | TPH1 (0.32) | — | |
| SCHEMBL30494535 | 0.81 | TPH1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708366-B2 | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2023-07-25 | — | — | US | disclosed |
| US-11708366-B2 | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | NOVARTIS AG (CH) | 2023-07-25 | — | — | US | disclosed |
| US-20220048909-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2022-02-17 | — | — | US | disclosed |