Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254574 | 0.85 | HPGD (0.51) | KMT2AMEN1APEX1 | |
| SCHEMBL15276206 | 0.80 | KMT2A (0.56) | KMT2AMEN1HCRTR1APEX1NPC1 | |
| SCHEMBL24254487 | 0.79 | NPC1 (0.54) | KMT2AMEN1HCRTR1APEX1NPC1 | |
| SCHEMBL15276210 | 0.77 | APEX1 (0.58) | KMT2AMEN1HCRTR1APEX1NPC1 | |
| SCHEMBL25045867 | 0.75 | HPGD (0.60) | KMT2AMEN1HCRTR1POLB | |
| SCHEMBL10318178 | 0.73 | NPC1 (0.53) | KMT2AMEN1HCRTR1APEX1NPC1 | |
| SCHEMBL13591202 | 0.71 | KMT2A (0.57) | KMT2AMEN1HCRTR1APEX1NPC1 | |
| SCHEMBL11773491 | 0.70 | HDAC1 (0.51) | KMT2AMEN1HCRTR1APEX1NPC1 | |
| SCHEMBL2905163 | 0.70 | RAB9A (0.62) | APEX1NPC1POLBTP53 | |
| SCHEMBL2908748 | 0.70 | NPC1 (0.54) | KMT2AMEN1HCRTR1APEX1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |