Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.57 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.57 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | RORC | P51449 | 2/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.48 |
| ▸ | NPY2R | P49146 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254508 | 0.90 | MEN1 (0.78) | MEN1KMT2ALMNAKCNJ6KCNJ5 | |
| SCHEMBL24254505 | 0.78 | LMNA (0.79) | MEN1KMT2ALMNAKCNJ6KCNJ5 | |
| SCHEMBL3222675 | 0.77 | MEN1 (0.51) | MEN1KMT2ALMNAKCNJ6KCNJ5 | |
| SCHEMBL25242669 | 0.76 | ALDH1A1 (0.61) | MEN1KMT2ALMNAKCNJ6KCNJ5 | |
| SCHEMBL24254506 | 0.76 | KMT2A (0.70) | MEN1KMT2ALMNAKCNJ6KCNJ5 | |
| SCHEMBL26188045 | 0.75 | ALDH1A1 (0.57) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL14426547 | 0.74 | MEN1 (0.68) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL25283909 | 0.74 | CA1 (0.54) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL2177704 | 0.73 | ALDH1A1 (0.58) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL16863775 | 0.72 | LMNA (1.00) | MEN1KMT2ALMNAKCNJ6KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |